[HTML][HTML] Tissue factor expressed by circulating cancer cell‐derived microparticles drastically increases the incidence of deep vein thrombosis in mice
Background The risk of thrombotic complications such as deep vein thrombosis (DVT)
during tumor development is well known. Tumors release into the circulation procoagulant
microparticles (MPs) that can participate in thrombus formation following vessel injury. The
importance of this MP tissue factor (TF) in the initiation of cancer‐associated DVT remains
uncertain. Objective To investigate how pancreatic cancer MPs promote DVT in vivo.
Methods We combined a DVT mouse model in which thrombosis is induced by flow …
during tumor development is well known. Tumors release into the circulation procoagulant
microparticles (MPs) that can participate in thrombus formation following vessel injury. The
importance of this MP tissue factor (TF) in the initiation of cancer‐associated DVT remains
uncertain. Objective To investigate how pancreatic cancer MPs promote DVT in vivo.
Methods We combined a DVT mouse model in which thrombosis is induced by flow …
