The pilocarpine model of temporal lobe epilepsy and EEG monitoring using radiotelemetry system in mice
JE Kim, KO Cho - JoVE (Journal of Visualized Experiments), 2018 - jove.com
Temporal lobe epilepsy (TLE) is a common neurological disorder in adulthood. For
translational studies of chronic epilepsy, pilocarpine-induced status epilepticus (SE) is
frequently selected to recapitulate spontaneous recurrent seizures (SRS). Here we present a
protocol of SE induction by intraperitoneal (ip) injection of pilocarpine and monitoring of
chronic recurring seizures in live animals using a wireless telemetry video and
electroencephalogram (EEG) system. We demonstrated notable behavioral changes that …
translational studies of chronic epilepsy, pilocarpine-induced status epilepticus (SE) is
frequently selected to recapitulate spontaneous recurrent seizures (SRS). Here we present a
protocol of SE induction by intraperitoneal (ip) injection of pilocarpine and monitoring of
chronic recurring seizures in live animals using a wireless telemetry video and
electroencephalogram (EEG) system. We demonstrated notable behavioral changes that …